From amines to diketopiperazines: a one-pot approach |
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Authors: | Elaine O’Reilly |
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Institution: | UCD School of Chemistry and Chemical Biology, Centre for Synthesis and Chemical Biology, Belfield, Dublin 4, Ireland |
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Abstract: | An efficient one-pot synthesis is described for the preparation of 1,4-disubstituted piperazine-2,5-diones starting from a suitable amine and chloroacetyl chloride in the presence of an aqueous base. The resulting chloroacetamide is cyclised in situ by employing the phase-transfer (PT) catalyst, benzyltriethylammonium chloride (TEBA). The products are isolated in excellent yields of up to 90%. |
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Keywords: | Diketopiperazine One-pot synthesis Phase-transfer catalyst Benzyltriethylammonium chloride |
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