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Novel polyisoprenylated benzophenone derivatives from Garcinia paucinervis |
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| Authors: | Xue-Mei Gao Fanny Shuk Fan Lai Chun-Feng Qiao Xin Liu Kathy Qian Luo Hong-Xi Xu |
| Institution: | a Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, N.T., Hong Kong, People’s Republic of China b Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore c State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People’s Republic of China |
| Abstract: | Four novel polyisoprenylated benzophenone derivatives, paucinones A-D (1-4), were isolated from the leaves of the plant Garcinia paucinervis. Paucinones A-C (1-3) contained an unexpected cyclohexane-spiro-tetrahydrofuran moiety. A 1-methylene-3,3-dimethylcyclohexane group never reported before was found in the structure of paucinone D (4). The structures of these compounds were elucidated with spectroscopic evidences. The relative stereochemistries of 1-4 were determined by NOESY correlations. These compounds showed significant cytotoxicities against HeLa cells. |
| Keywords: | Garcinia paucinervis Benzophenone Cytotoxicity HeLa cell |
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