Synthesis and Suzuki-Miyaura reactions of 5-halo-3,4-dihydropyrimidin-2(1H)-ones |
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Authors: | Andrew J Zych Hong-Jun Wang Samuel A Sakwa |
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Institution: | Medicinal Chemistry Department, AMRI, 26 Corporate Circle, PO Box 15098, Albany, NY 12212-5098, USA |
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Abstract: | A novel synthesis of 6-methyl-4-phenyl-5-substituted-3,4-dihydropyrimidin-2(1H)-ones from 6-methyl-4-phenyl-5-halo-3,4-dihydropyrimidin-2(1H)-ones via the Suzuki-Miyaura reaction is reported. These previously unknown heterocyclic halides are easily prepared using the Biginelli multicomponent reaction followed by halodecarboxylation. The effect of varied substitution at the C-4 position on the cross-coupling reaction is also examined. |
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