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Progress towards the total synthesis of 2,3-dihydroxytrinervitanes |
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| Authors: | Jhillu Singh Yadav Swapan Kumar Biswas Sandip Sengupta |
| Institution: | Organic Chemistry Division-I, Indian Institute of Chemical Technology (CSIR), Hyderabad 500 007, India |
| Abstract: | Intramolecular Diels-Alder approach to construct the fused AB ring of trinervitane has been demonstrated efficiently. The key intermediate for the Diels-Alder cyclization has been achieved following highly stereoselective Julia-Kocienski olefination, Sharpless epoxidation and Evan’s asymmetric alkylation as the key reactions. |
| Keywords: | Trinervitanes Intramolecular Diels-Alder reaction Julia-Kocienski olefination Evan&rsquo s asymmetric alkylation |
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