Synthetic construction of a fucosyl chitobiose as an allergen-associated carbohydrate epitope and the glycopolymer involving highly clustered trisaccharidic sequences |
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Authors: | Koji Matsuoka Hiroki Yamaguchi Tetsuo Koyama Ken Hatano Daiyo Terunuma |
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Institution: | Area for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan |
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Abstract: | Synthetic construction of fucosyl chitobiose GlcNAcβ1→4(Fucα1→3)GlcNAc] as an allergy-associated carbohydrate epitope was accomplished from three building blocks. The trisaccharidic unit was further transformed into a carbohydrate monomer and polymerization of the glycomonomer proceeded smoothly to provide a series of glycopolymers having various carbohydrate densities. In addition to the organic syntheses, biological evaluations of the glycomonomer and the polymers were carried out and sugar-clustering effects were observed. |
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Keywords: | Plant carbohydrate chains Fucosyl chitobiose Glycosides Glycopolymers Glycoclusters |
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