A simple and convenient synthesis of substituted furans and pyrroles by CuCl2-catalyzed heterocyclodehydration of 3-yne-1,2-diols and N-Boc- or N-tosyl-1-amino-3-yn-2-ols |
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| Authors: | Bartolo Gabriele Pierluigi Plastina Lucia Veltri Giuseppe Salerno |
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| Affiliation: | a Dipartimento di Scienze Farmaceutiche, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy
b Dipartimento di Chimica, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy |
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| Abstract: | A simple and economical synthesis of substituted furans and pyrroles, by ligand-free CuCl2-catalyzed heterocyclodehydration of readily available 3-yne-1,2-diols and N-Boc- or N-tosyl-1-amino-3-yn-2-ols, respectively, is presented. Reactions are carried out in MeOH at 80-100 °C for 1-24 h and afford the corresponding heterocyclic derivatives in 53-99% isolated yields. |
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| Keywords: | Copper Cyclization Heterocycles Furans Pyrroles |
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