Département de Chimie, Université Laval, Quebec City, Que., Canada G1V 0A6
Abstract:
The first synthesis of rubrolide L, a marine ascidian butenolide and a potent inhibitor of human aldose reductase, has been achieved by two tactically distinct pathways in 4-5 steps and 37-42% overall yield from commercially available 3-chlorotetronic acid.