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Synthesis of the human aldose reductase inhibitor rubrolide L |
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| Authors: | John Boukouvalas Lucas C McCann |
| Institution: | Département de Chimie, Université Laval, Quebec City, Que., Canada G1V 0A6 |
| Abstract: | The first synthesis of rubrolide L, a marine ascidian butenolide and a potent inhibitor of human aldose reductase, has been achieved by two tactically distinct pathways in 4-5 steps and 37-42% overall yield from commercially available 3-chlorotetronic acid. |
| Keywords: | Diabetes Selective bromination Suzuki-Miyaura cross-coupling Vinylogous aldol condensation |
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