Fluorescein derivative-based, selective and sensitive chemosensor for NADH |
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| Authors: | Sang Oh Jung Sudeok Kim Mi Hee Kim Seong Hyeok Seo Seung Kyung Kim Suk-Kyu Chang |
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| Institution: | a Department of Chemistry, POSTECH, San 31, Hyojadong, Namgu, Pohang, Kyungbuk 790-784, Republic of Korea
b Department of Chemistry, Chung-Ang University, Seoul 156-756, Republic of Korea |
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| Abstract: | Fluorescein mercury acetate (FMA) derivative can be used as a chemosensor for NADH that plays key roles in cellular energy metabolism and dehydrogenase enzymatic reactions. The sensor recognizes NADH by two mercury metal ions in the compound using the metal-anion interaction and its subsequent binding-induced fluorescence changes of FMA. The FMA can detect an aqueous NADH concentration of approximately 1.0 μM and has a high selectivity over various anions including NAD+, the oxidized form of NADH. |
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