Efficient ligand-free copper-catalyzed C-S cross-coupling of thiols with aryl iodides using KF/Al2O3 as base |
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| Authors: | Yi-Si Feng Yuan-Yuan Li Wei Wu |
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| Affiliation: | a School of Chemical Engineering, Hefei University of Technology, Hefei 230009, PR China
b Anhui Key Laboratory of Controllable Chemical Reaction & Material Chemical Engineering, Hefei 230009, PR China |
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| Abstract: | We report a mild, convenient, environmentally friendly, and ligand-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % CuI with KF/Al2O3 as the base, in DMF at 110 °C. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excellent yields from readily available iodides and thiols. |
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