Efficient chromatography-free synthesis of the oxy-analogue of fingolimod |
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Authors: | Aleksandra Zivkovic |
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Affiliation: | Johann Wolfgang Goethe University, Institute of Pharmaceutical Chemistry, Biozentrum, ZAFES/CMP/ICNP, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany |
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Abstract: | Fingolimod (FTY720) and its analogue derivatives are not only promising therapeutics in sphingolipid signaling but also valuable tools for understanding the roles of sphingolipids in (patho)physiological conditions. A practical method for the synthesis of the ether analogue of FTY720 is described. Our final synthetic approach allows high yield and efficient synthesis of O-FTY in only four steps without chromatographic purifications. |
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Keywords: | Sphingolipids Fingolimod Synthesis Chromatography-free |
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