Synthesis of optically pure 2,3,4-trisubstituted tetrahydrofurans via a two-step sequential Michael-Evans aldol cyclization strategy: total synthesis of (+)-magnolone |
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Authors: | Ganesh Pandey Srikanth Luckorse Vedavati G Puranik |
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Institution: | a Division of Organic Chemistry, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India b Center for Material Characterization, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India |
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Abstract: | Synthesis of optically pure 2,3,4-trisubstituted tetrahydrofurans is described employing a two-step Michael-Evans aldol cyclization strategy. The approach is successfully applied for the total synthesis of furano lignan natural product (+)-magnolone. |
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Keywords: | Tetrahydrofuran Lignans Magnolone HWE reaction Michael-Evans aldol reaction |
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