A new Yb-catalyzed pinacol and imine-coupling reaction |
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| Authors: | Helen C. Aspinall Nicholas Greeves Shane Lo Fan Hin |
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| Affiliation: | Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK |
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| Abstract: | Ytterbium triflate, Yb(OTf)3, catalyzes the intermolecular reductive homocouplings of imines, aldehydes, and ketones at loadings of 5 mol % in the presence of Mg and Me3SiCl to give isolated yields of up to 95%. Diastereoselectivity of up to 4/96 (dl/meso) is achieved for aromatic aldehydes, up to 100% dl for aliphatic aldehydes, and 100% dl for an intramolecular imine coupling. |
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