Access to the nicotine system by application of a guanidine-catalyzed asymmetric Michael addition of diphenyliminoacetate with 3-pyridyl vinyl ketone |
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| Authors: | Gang Zhang |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan |
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| Abstract: | A guanidine-based chiral organocatalyst was successfully applied to the Michael addition of diphenyliminoacetate to pyridyl vinyl ketone as a key reaction for the construction of the nicotine system. |
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| Keywords: | Nicotine Organocatalysis Michael addition Pyridyl vinyl ketone |
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