Synthesis of 4-allylquinazolines from N-(2-cyanoaryl)amides via the In-mediated allylation of nitrile and dehydrative cyclization cascade |
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| Authors: | Sung Hwan Kim Taek Hyeon Kim |
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| Affiliation: | a Department of Chemistry and Institute of Basic Science, Chonnam National University, Gwangju 500-757, Republic of Korea
b Department of Applied Chemistry and Center for Functional Nano Fine Chemicals, Chonnam National University, Gwangju 500-757, Republic of Korea |
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| Abstract: | The reaction of allylindium reagents and N-(2-cyanoaryl)amides afforded 2-substituted-4-allylquinazolines in good yields via the indium-mediated Barbier-type allylation of nitrile and the following dehydrative cyclization cascade. |
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| Keywords: | Quinazolines Indium Nitrile Allylation Barbier reaction |
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