The use of polyhedral oligomeric silsesquioxane (POSS) as a soluble support for organic synthesis: A case study with a POSS-bound isocyanate scavenger reagent |
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| Authors: | Mark York Richard A. Evans |
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| Affiliation: | CSIRO Molecular and Health Technologies, Bag 10, Clayton South, Victoria 3169, Australia CSIRO Future Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia Cooperative Research Centre for Polymers, 8 Redwood Drive, Notting Hill, Victoria 3168, Australia |
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| Abstract: | The use of polyhedral oligomeric silsesquioxane (POSS) as a soluble support in organic synthesis is reported. A POSS-bound isocyanate was readily synthesised in one step from commercially available starting materials and was isolated in high yield and purity by simple filtration. It was found to perform well as a scavenger for excess amine in the solution phase synthesis of amides and sulfonamides, allowing product isolation in high yield and purity. |
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| Keywords: | POSS Scavenger Soluble support |
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