Synthesis of (Z)-1-benzylidene-3-(1H-indol-1-yl)-1H-indene-2,2(3H)-dicarbonitriles via three-component reaction of 2-alkynylbenzaldehyde, malononitrile, and indole |
| |
| Authors: | Guanyinsheng Qiu Yiyuan Peng Jie Wu |
| |
| Affiliation: | a Key Laboratory of Green Chemistry of Jiangxi Province, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330027, China
b Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China |
| |
| Abstract: | Three-component reaction of 2-alkynylbenzaldehyde, malononitrile, and indole under mild conditions is described, which generates the desired (Z)-1-benzylidene-3-(1H-indol-1-yl)-1H-indene-2,2(3H)-dicarbonitriles in moderate to good yields. This reaction proceeds smoothly with high selectivity. The tandem condensation, nucleophilic addition, and 5-exo-cyclization may be involved in the process. |
| |
| Keywords: | 2-Alkynylbenzaldehyde Malononitrile Indole Three-component reaction |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
