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The allylic nucleophilic substitution of Morita-Baylis-Hillman acetates with isocyanides: a facile synthesis of trisubstituted olefins |
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| Authors: | J.S. Yadav B.V. Subba Reddy Ashutosh Pratap Singh Nilanjan Majumder |
| Affiliation: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | Morita-Baylis-Hillman acetates undergo smooth allylic nucleophilic substitution (SN2′) with tosylmethyl isocyanide (TosMIC) in the presence of a catalytic amount of BF3·OEt2 under mild conditions to furnish trisubstituted olefins in high yields with (E)-stereoselectivity. |
| Keywords: | Morita-Baylis-Hillman acetates SN2&prime substitution TosMIC Alkylation |
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