Histone deacetylase inhibitors: synthesis of cyclic tetrapeptides and their triazole analogs |
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| Authors: | Erinprit K. Singh |
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| Affiliation: | Department of Chemistry and Biochemistry, 5500 Campanile Dr., San Diego State University, San Diego, CA 92182-1030, USA |
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| Abstract: | Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives is described. HDAC inhibitory activity of these compounds against HeLa cell lysate is evaluated. The biological data demonstrate that incorporation of a triazole unit improves the HDAC inhibitory activity. |
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