An enantioselective synthesis of the bicyclic core of the marine natural product awajanomycin |
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| Authors: | Deiniol R Pritchard |
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| Institution: | Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK |
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| Abstract: | A concise stereoselective synthesis of the N-benzylated bicyclic core of the marine natural product awajanomycin is described starting with naturally occurring l-alanine. Key steps in the synthesis include a ring-closing metathesis to establish a δ-lactam ring followed by a stereoselective hydroxylation to instal the quaternary centre. |
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| Keywords: | Ring-closing metathesis δ-Lactam Acremonium sp Diastereoselective hydroxylation |
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