Convenient Stille carbonylative cross-couplings using molybdenum hexacarbonyl |
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| Authors: | Jonas Lindh Maria Almeida |
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| Affiliation: | a Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala Biomedical Center, Uppsala University, PO Box 574, SE-751 23 Uppsala, Sweden
b Dirigentvägen 160, SE-756 54, Uppsala, Sweden |
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| Abstract: | Palladium catalysis was used in Stille-type carbonylative cross-couplings employing Mo(CO)6 as the carbon monoxide source. Robust and convenient transformations were carried out in closed vessels at 100 °C, providing a set of diaryl ketones in good yields. Aryl triflates and bromides were used as coupling partners with aryl stannanes. Inclusion of the Mo(CO)6 destabilizing agent DBU made this protocol operationally simple and suppressed side-product formation. |
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| Keywords: | Stille Molybdenum hexacarbonyl Diaryl ketones Palladium |
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