Synthesis of 6-substituted 5-cyano-7-hydroxy-2-carboxybenzofurans |
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Authors: | Simon J. Teague Simon Barber |
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Affiliation: | Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough LE11 5RH, UK |
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Abstract: | Methods for the synthesis of 5-cyano-7-hydroxy-2-carboxybenzofurans bearing a variety of substituents at the 6-position are outlined. The scope and limitations of lithiation processes, electrophilic substitutions, and pericyclic reactions are investigated. |
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