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Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis |
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| Authors: | Jun-Ting Fan Yi-Shan Chen Wen-Yan Xu Liangcheng Du Yu-Mei Zhang Yan Li |
| Affiliation: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China b Graduate School of Chinese Academy of Sciences, Beijing 100039, PR China c Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, USA |
| Abstract: | Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages. |
| Keywords: | Rubia yunnanensis Rubiyunnanin A Rubiyunnanin B Cyclopeptides Cytotoxicity Inhibition of NO production |
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