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An efficient and scalable synthesis of N-(benzyloxycarbonyl)- and N-(methyloxycarbonyl)-(S)-vinylglycinol |
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| Authors: | Alexandre Lumbroso Isabelle Beaudet |
| Institution: | Université de Nantes, CNRS, Chimie Et Interdisciplinarité: Synthèse, Analyse et Modélisation (CEISAM), UMR CNRS 6230, Faculté des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France |
| Abstract: | An efficient and scalable synthesis of N-(benzyloxycarbonyl)- and N-(methyloxycarbonyl)-(S)-vinylglycinol has been reported starting from the commercially available (l)-methionine. The scale-up preparation consisted of 5 steps and delivered up to 50 g of the desired N-protected β-amino alcohols in 32% and 36% overall yields. |
| Keywords: | Chiral β-amino alcohol Vinylglycine Amino acid Preparative procedure |
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