|
|||||
|
|
An expedient synthesis of ellipticine via Suzuki-Miyaura coupling |
|
| Authors: | Takeo Konakahara Y.B. Kiran Reiko Ikeda Norio Sakai |
| Affiliation: | a Department of Pure and Applied Chemistry, Faculty of Science & Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan b Research Institute for Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan c Center for Technologies against Cancer, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan |
| Abstract: | A simple and efficient total synthesis of ellipticine was developed via the Suzuki-Miyaura coupling of sterically sensitive 2-hydroxybenzeneboronic acid with a multifunctional aryl halide using Pd(OAc)2 as a catalyst and Cu(OAc)2·H2O as an additive in DMSO/H2O as a key step followed by double N-arylation and cyclization. |
| Keywords: | Ellipticine Suzuki-Miyaura coupling Formylation Steric sensitivity Double N-arylation |
| 本文献已被 ScienceDirect 等数据库收录！ | |