Design and synthesis of novel spirocyclopropyl cyclohexane-1,3-diones and -1,3,5-triones for their incorporation into potent HPPD inhibitors |
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| Authors: | Renaud Beaudegnies Alain De Mesmaeker Aurélie Mallinger Myriam Baalouch André Goetz |
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| Institution: | Syngenta Crop Protection AG, Crop Protection Research, Research Chemistry, Schaffhauserstr. 101, CH-4332 Stein, Switzerland |
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| Abstract: | We report the design and the efficient synthesis of novel spirocyclopropyl cyclohexane-1,3-dione and -1,3,5-trione units to be incorporated into potent HPPD inhibitors. New routes involving original combinations of synthetic equivalents of α-cyclopropyl ketone-α-anion and α-cyclopropyl ester-β-cation are described. |
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| Keywords: | Spirocyclopropane α-Cyclopropyl ketone-α-anion α-Cyclopropyl ester-β-cation Decarboxylative ring contraction |
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