Synthesis and biological evaluation of indole-3-carboxamide derivatives as antioxidant agents |
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| Authors: | Erfang Huang Lan Zhang Chuying Xiao Guangpeng Meng Bingqi Zhang Jianshu Hu David Chi-Cheong Wan Qingguo Meng Zhe Jin Chun Hu |
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| Affiliation: | Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; Department of Pharmacy, Yantai Univeristy, Yantai 264005, China |
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| Abstract: | Oxidative stress results in various pathologies and as consequence antioxidant agents have attracted uninterrupted attention. In this paper, a novel series of indole-3-carboxamide derivatives (6a-6l) were designed and synthesized based on the melatonin structure as novel antioxidants. All of them were evaluated for the antioxidant activities in vitro against human neuroblastoma SH-SY5Y cell line using H2O2 radical scavenging assay. The target compounds 6a, 6f and 6i indicated better activities than the positive control, ascorbic acid, and 6a exhibited the best antioxidant activity. In addition, the structureactivity relationships of the target compounds were also preliminarily summarized based on the obtained experimental data. |
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| Keywords: | Heterocycle Melatonin Indole-3-carboxamide derivatives Synthesis Antioxidant activity Structure-activity relationship |
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