Synthesis of (+)-nocardione A--use of formal radical cyclization onto a benzene ring |
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| Authors: | Clive Derrick L J Fletcher Stephen P |
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| Affiliation: | Chemistry Department, University of Alberta, Edmonton, Alberta, Canada T6G 2G2. derrick.clive@ualberta.ca |
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| Abstract: | Juglone (7) was converted into enone 13; this underwent radical cyclization to afford 15, which was aromatized to 16 and elaborated into (+)-nocardione A (1), the enantiomer of the naturally-occurring tyrosine phosphatase inhibitor (-)-nocardione A (2). |
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