A novel four-component reaction for the synthesis of functionalised dihydropyrimidines |
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| Authors: | Vugts Danielle J Jansen Helen Schmitz Rob F de Kanter Frans J J Orru Romano V A |
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| Institution: | Department of Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands. |
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| Abstract: | In a multi-component reaction (MCR) of a phosphonate, nitriles, aldehydes and isocyanates, N3-functionalised dihydropyrimidines can be synthesised efficiently via a Horner-Emmons/aza Diels-Alder pathway. |
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