Synthesis and reactivity of enediynyl amino acids and peptides: a novel concept in lowering the activation energy of Bergman cyclisation by H-bonding and electrostatic interactions |
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| Authors: | Basak Amit Bag Subhendu Sekhar Bdour Hussam M M |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India. absk@chem.iitkgp.ernet.in |
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| Abstract: | Novel enediynyl amino acids and peptides 3 and 5-8 were synthesized and their thermal reactivity towards Bergman cyclization studied and compared with the earlier reported amino acid 4, which demonstrated, for the first time, the effect of H-bonding and electrostatic interactions in lowering the activation energy of Bergman cyclization. |
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