Programmed‐Assembly System Using DNA Jigsaw Pieces |
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| Authors: | Masayuki Endo Dr. Tsutomu Sugita Yousuke Katsuda Kumi Hidaka Hiroshi Sugiyama Prof. Dr. |
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| Affiliation: | 1. Institute for Integrated Cell‐Material Sciences (iCeMS), Kyoto University, Yoshida‐ushinomiyacho, Sakyo‐ku, Kyoto 606‐8501 (Japan), Fax: (+81)?75‐753‐3670;2. CREST Japan Science and Technology Corporation (JST), Sanbancho, Chiyoda‐ku, Tokyo 102‐0075 (Japan);3. Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa‐oiwakecho, Sakyo‐ku, Kyoto 606‐8502 (Japan) |
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| Abstract: | A novel method for assembling multiple DNA origami structures has been developed by using designed 2D DNA origami rectangles, so‐called “DNA jigsaw pieces” that have sequence‐programmed connectors. Shape and sequence complementarity were introduced to the concavity and convex connectors in the DNA rectangles for selective connection with the help of nonselective π‐stacking interactions between the side edges of the DNA jigsaw piece structures. Single DNA jigsaw piece units were assembled into unidirectional nanostructures with the correct alignment and uniform orientation. Three and five different DNA jigsaw pieces were assembled into predesigned and ordered nanostructures in a programmed fashion. Finally, three‐, four‐, and five‐letter words have been displayed by using this programmed DNA jigsaw piece system. |
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| Keywords: | DNA structures nanostructures nanotechnology self‐assembly supramolecular chemistry |
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