Pd‐Catalyzed C?N Bond Formation with Heteroaromatic Tosylates |
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| Authors: | Mette L H Mantel Anders T Lindhardt Dr Daniel Lupp Troels Skrydstrup Prof Dr |
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| Institution: | The Center for Insoluble Protein Structures (inSPIN), Department of Chemistry and the Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C (Denmark), Fax: (+45)?8619‐6199 |
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| Abstract: | A protocol for the palladium(0)‐catalyzed amidation of heteroaromatic tosylates was successfully developed. The methodology proved to be effective for a variety of heteroaryl tosylates including the pyridine, pyrimidine, quinoline and quinoxaline ring systems. Successful carbon? nitrogen bond formation with these heteroaryl tosylates could be performed with a wide range of primary amides, oxazolidinones, lactams, anilines and indoles, including one cyclic urea. Moreover, this C? N bond forming reaction provided products with high structural diversity. The coupling reaction was also amenable to scale up applications. |
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| Keywords: | aryl tosylates heterogeneous catalysis C?N bond formation heterocycles palladium |
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