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Flower‐Like Hierarchically Nanostructured Hydroxyapatite Hollow Spheres: Facile Preparation and Application in Anticancer Drug Cellular Delivery |
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| Authors: | Ke‐Wei Wang Prof. Dr. Ying‐Jie Zhu Xiao‐Yan Chen Wan‐Yin Zhai Qi Wang Feng Chen Prof. Dr. Jiang Chang Prof. Dr. You‐Rong Duan |
| Affiliation: | 1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China), Fax: (+86)?21‐52413122;2. Cancer Institute of Shanghai Jiao Tong University, Shanghai, 200032 (P.R. China);3. Key Laboratory of Drug Targeting of Ministry of Education, School of Pharmacy, Sichuan University, Chengdu, 610041 (P.R. China) |
| Abstract: | Flower‐like nanostructured hydroxyapatite hollow spheres (NHHS) assembled with nanosheets with a hierarchical morphology are fabricated by a rapid microwave‐assisted hydrothermal route. The presence and concentration of block copolymer poly(lactide)‐block‐poly(ethylene glycol) (PLA–PEG) are important parameters for the formation of the hollow structure. The possible formation mechanism of NHHS is proposed. The NHHS are explored as anticancer drug carriers for cellular delivery of mitoxantrone (MIT). The MIT‐loaded NHHS exhibit sustained‐drug‐release behavior in vitro and the intracellular drug‐distribution tests indicate that the MIT loaded in NHHS carriers can enter the cells efficiently. The experiments also show that the NHHS have a good biocompatibility, and therefore, they are promising anticancer drug carriers in cancer chemotherapy. |
| Keywords: | block copolymers cancer drug delivery microwave chemistry nanostructures |