Sesquiterpene Lactones from Daucus glaber |
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| Authors: | Amal A Sallam Yukio Hitotsuyanagi El‐Sayed S Mansour Atallah F Ahmed Sahar Gedara Haruhiko Fukaya Koichi Takeya |
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| Institution: | 1. Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt;2. School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432‐1 Horinouch, Hachioji, Tokyo 192‐0392, Japan, (phone: +81‐426‐76‐3007;3. fax: +81‐426‐77‐1436) |
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| Abstract: | Six new sesquiterpene lactone esters, daucoguaianolactones A–F ( 1 – 6 ), and one new sesquiterpene lactone, daucoeudesmanolactone A ( 7 ) were isolated from the leaves and stems of Daucus glaber (Forssk .) Thell ., along with the known sesquiterpene lactones talasins A and B and badkhysin. The structures of 1 – 6 were established on the basis of extensive 1D‐ and 2D‐NMR spectroscopic studies and that of 7 by X‐ray crystallography. Compounds 4, 7 , and talasins A and B showed moderate cytotoxicity against P‐388 leukemia cells. |
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| Keywords: | Daucus glaber Sesquiterpene lactone esters Lactones Daucoguaianolactones A – F Daucoeudesmanolactone A |
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