Quantification of ion-induced molecular fragmentation of isolated 2-deoxy-D-ribose molecules |
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Authors: | Alvarado Fresia Bari Sadia Hoekstra Ronnie Schlathölter Thomas |
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Institution: | KVI Atomic Physics, Rijksuniversiteit Groningen, Zernikelaan 25, NL-9747AA, Groningen, The Netherlands. alvarado@kvi.nl |
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Abstract: | Recent experiments on low energy ion-induced damage to DNA building blocks indicate that ion induced DNA damage is dominated by deoxyribose disintegration (Phys. Rev. Lett., 2005, 95, 153201). We have studied interactions of keV H+ and He(q+) with isolated deoxyribose molecules by means of high resolution time-of-flight spectrometry. Extensive statistical fragmentation of the molecules is observed. The fragment distribution is found to follow a power law dependence. The exponent can be used to characterize and quantify the molecular damage. |
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