Combined synthetic/CD strategy for the stereochemical assignment of the tricarballylic acid side chains of fumonisin B(1) |
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Authors: | Hartl M Humpf H U |
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Institution: | Lehrstuhl für Lebensmittelchemie, Universit?t Würzburg, Am Hubland, 97074 Würzburg, Germany. |
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Abstract: | The circular dichroism (CD) exciton chirality method was employed for the stereochemical assignment of the tricarballylic acid (TCA) side chains of fumonisin B(1) 1a (FB(1)). Using 2-naphthoate for chromophoric derivatization of the reduced TCA moieties, the absolute configuration was shown to be R. For additional confirmation, an optically active dihydroxy-tert-butanoate 2 related to the TCA group of fumonisin B(1) was synthesized to serve as a model compound. |
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