Fabrication of biofunctional complex micelles with tunable structure for application in controlled drug release |
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Authors: | Lizhi Zhao Chenglin Wu Fang Wang Anguo Ying Chendiao Xu Shaofei Liu |
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Institution: | 1. State Key Laboratory of Hollow Fiber Membrane Materials and Processes; School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin, 300380, People’s Republic of China 2. School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, 317000, Zhejiang Province, People’s Republic of China
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Abstract: | In acidic solution, complex micelles were formed by diblock copolymers of poly (ethylene glycol)-b-poly (ε-caprolactone) (PEG-b-PCL) and folate-poly (2-(dimethylamino) ethyl methylacrylate)-b-poly (ε-caprolactone) (Fol-PDMAEMA-b-PCL) with a PCL core, a mixed PEG/Fol-PDMAEMA shell. The surface charge of the complex micelles was positive at acidic surroundings for the protonated PDMAEMA. With increasing pH value to 7.4 (above pK a of PDMAEMA), these micelles could convert into a core-shell-corona (CSC) structure composing a hydrophobic PCL core, a collapsed PDMAEMA shell, and a soluble PEG corona. Compared to core-shell micelles formed by PEG-b-PCL, micelles with CSC structure can prolong degradation by enzyme. Doxorubicin was physically loaded into the PCL core. The drug release rate was pH-dependent. At pH 5.5, complex micelles with core-shell structure showed faster drug release rate, while at pH 7.4, complex micelles gained CSC structure which control the drug release at a lower rate. The multifunctional complex micelles were prepared for enhanced tumor therapy. |
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