Dorsal horn-enriched genes identified by DNA microarray, in situ hybridization and immunohistochemistry |
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Authors: | Hong Sun Jian Xu Kimberly B Della Penna Robert J Benz Fumi Kinose Daniel J Holder Kenneth S Koblan David L Gerhold Hao Wang |
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Institution: | (1) Department of Molecular Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA;(2) Department of Molecular Profiling, Merck Research Laboratories, West Point, PA 19486, USA;(3) Department of Biometrics Research, Merck Research Laboratories, West Point, PA 19486, USA |
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Abstract: | Background Neurons in the dorsal spinal cord play important roles in nociception and pain. These neurons receive input from peripheral sensory neurons and then transmit the signals to the brain, as well as receive and integrate descending control signals from the brain. Many molecules important for pain transmission have been demonstrated to be localized to the dorsal horn of the spinal cord. Further understanding of the molecular interactions and signaling pathways in the dorsal horn neurons will require a better knowledge of the molecular neuroanatomy in the dorsal spinal cord. |
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