| 三价铁对灯盏花素与牛血清白蛋白相互作用的影响 |
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| 引用本文： | 张怀斌,荣先国. 三价铁对灯盏花素与牛血清白蛋白相互作用的影响[J]. 化学研究, 2013, 0(3): 224-227 |
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| 作者姓名： | 张怀斌 荣先国 |
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| 作者单位： | 滨州医学院(烟台校区)药学院 |
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| 基金项目： | 山东省高等学校科技计划资助项目(J12LD55);滨州医学院科研专项资助项目(BY2009KJ30) |
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| 摘 要： | 运用荧光光谱、紫外吸收光谱探讨了Fe3+对灯盏花素(BR)与牛血清白蛋白(BSA)相互作用的影响;从Fe3+与BSA的静电作用、配位结合以及Fe3+与BR的配位作用等方面分析了影响BR与BSA相互作用的因素.结果表明,Fe3+不改变BSA与BR的作用机制,但使得二者结合的猝灭常数、结合常数及结合位点数减小.
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| 关 键 词： | Fe3+ 灯盏花素 牛血清白蛋白 相互作用 |
Effect of ferric iron on interaction between breviscapinun and bovine serum albumin |
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| ZHANG Huai-bin,RONG Xian-guo. Effect of ferric iron on interaction between breviscapinun and bovine serum albumin[J]. Chemical Research, 2013, 0(3): 224-227 |
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| Authors: | ZHANG Huai-bin RONG Xian-guo |
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| Affiliation: | (Pharmaceutical College,Binzhou Medical University,Yantai 264003,Shandong,China) |
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| Abstract: | The effect of ferric iron （Fe3＋ ） on the interaction between breviscapinun （BR） and bovine serum albumin （BSA） was investigated by means of fluorescence spectrometry and ul- traviolet absorption spectrometry. The factors influencing the interaction between BR and BSA were analyzed in relation to the static action and coordination of Fe3＋ and BSA as well as the coordination action between Fe3＋ and BR. Results indicate that Fea＋ does not change the mech- anism for BSA to interact with BR, but it contributes to reduce the quenching constant, bind ing constant and binding sites of BSA with BR. |
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| Keywords: | Fe3＋ breviseapinun bovine serum albumin interaction |
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