1. Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentska 573 HB/D, CZ-530 09, Pardubice, Czech Republic 2. Institute of Environmental and Chemical Engineering, Faculty of Chemical Technology, University of Pardubice, Studentska 573 HB/D, CZ-530 09, Pardubice, Czech Republic
Abstract:
This work shows the analytical potential of inductively coupled plasma orthogonal-acceleration time-of-flight mass spectrometry (ICP-OA-TOF-MS) for rapid, simultaneous, and reliable determination of more than 50 elements at ultra-trace levels in urine. Under optimum instrumental conditions, after a 10-fold sample dilution step, and by using Rh as an internal standard, ICP-OA-TOF-MS also enables the determination of elements whose assay is more diffcult when using conventional quadrupole instruments. This is confirmed by the analysis of commercially available reference urine samples and/or by analytical recoveries study and isotope ratio based determination of accuracies. On the other side, the interference resulting from polyatomic carbon, chlorine, or various sulfur species does not allow the determination of elements such as Cr, Fe, V, Se and As without a mathematical correction.
Figure
Part of the ICP-TOF-MS mass spectra recorded from SeronormTM Trace Elements Urine Lot 0511545 diluted in 1+9 ratio with water