Acid-catalyzed tandem thiol switch for preparing peptide thioesters from mercaptoethyl esters |
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| Authors: | Eom Khee Dong Tam James P |
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| Institution: | School of Biological Sciences, Nanyang Technological University, Singapore. |
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| Abstract: | An efficient method compatible with Fmoc synthesis for preparing peptide thioesters via an acid-catalyzed tandem "thiol switch" of esters is described first by an intramolecular O-S acyl shift and then by an intermolecular S-S exchange, with concurrent deblocking of side chain protection groups. |
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