| A Novel Method for the Synthesis of Bioactive Benzimidazolyl-Phenoxyacetic Acid O-Acetylglucosyl Saccharide Esters |
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| 作者姓名： | CHEN Hong~ CHEN Yunhua~ OU Chunyan~ HUANG Siqing~ . |
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| 作者单位： | CHEN Hong~1，CHEN Yunhua~2，OU Chunyan~1，HUANG Siqing~ 1 1. Department of Applied Chemistry，Guangdong Ocean University，Zhanjiang 524088，Guangdong，China; 2. Department of Chemistry，Nanchang University，Nanchang 330047，Jiangxi，China |
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| 基金项目： | SupportedbytheDepartmentofEducationofGuangdongProvinceNaturalScienceFoundationofChina(Z03047) |
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| 摘 要： | 0Introduction Anumberofauthorshavereportedthebioactivityofbenzimid azoleanditsderivatives,andofthearyloxycarboxylicacids.Theyareappliedwidelyinagriculturalandmedicinalchemistry,as wellasplantvirusinhibitors13].4Dimethylaminopyridine(DMAP)haslightstrawcolouredor colourlesscrystals,whichwerediscoveredinthe1960sasanewtypeofnucleophilicreactioncatalyst.Theyhavebeenappliedwide lyinorganicsynthesis4,5].DMAPcanefficientlycatalyseesterifi cationreactions,butithasbeenrarelyreportedasacatalystfort…
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| 收稿时间： | 3 June 2005 |
A Novel Method for the Synthesis of Bioactive Benzimidazolyl-Phenoxyacetic Acid O-Acetylglucosyl Saccharide Esters |
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| CHEN Hong,CHEN Yunhua,OU Chunyan,HUANG Siqing ..A Novel Method for the Synthesis of Bioactive Benzimidazolyl-Phenoxyacetic Acid O-Acetylglucosyl Saccharide Esters[J].Wuhan University Journal of Natural Sciences,2006,11(2):419-422. |
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| Authors: | CHEN Hong CHEN Yunhua OU Chunyan HUANG Siqing |
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| Institution: | (1) Department of Applied Chemistry, Guangdon Ocean University, 524088 Zhanjiang, Guangdon, China;(2) Department of Chemistry, Nanchang University, 330047 Nanchang, Jiangxi, China |
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| Abstract: | A novel method of synthesis of nitro or trifluoromethyl substituted benzimidazolyl-phenoxyacetic acid O-acetylglucosyl saccharide esters by the reaction of O-acetylglucosyl bromide with substituted benzimidazolyl -phenoxyacetic acid at room temperature was developed. 4-dimethylaminopyridine (DMAP) was used as catalyst, triethylamine (Et_3N) was used as deacid reagent, three saccharide esters were synthesized in the system of DMAP/ Et_3N. The catalytic mechanism of DMAP/Et_3N was discussed. The results show that DMAP is an effective catalyst, the yields can reach 50%. The test indicates that the title compounds show better antiplantviral activity. |
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| Keywords: | benzimidazolyl-phenoxyacetic acid O-acetylglucosyl saccharide ester antiplantviral activity DMAP/Et3N |
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