Polyfunctional imidazoles: II. Synthesis and reactions with nucleophilic reagents of 1-substituted 2,4-dichloro-1H-imidazole-5-carbaldehydes |
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| Authors: | V. A. Chornous A. M. Grozav E. B. Rusanov A. M. Nesterenko M. V. Vovk |
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| Affiliation: | 1.Bukovinskii State Medical University,Chernovtsy, Chernovtsy,Ukraine;2.Institute of Organic Chemistry,National Academy of Sciences of Ukraine,Kyiv,Ukraine |
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| Abstract: | 1-Alkyl(aryl)imidazolidine-2,4-diones reacted with Vilsmeier-Haack reagent affording 1-alkyl(aryl)-2,4-dichloro-1H-imidazole-5-carbaldehydes whose reactions with sodium azide, sodium alkoholates, with phenols, thiols, and secondary cycloalkylamines led to the substitution of chlorine in the position 2 of the imidazole ring. The reaction with primary amines resulted in the condensation products at the aldehyde group. |
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