Rhodium-catalyzed asymmetric cyclization/hydroboration of 1,6-enynes |
| |
Authors: | Kinder Robert E Widenhoefer Ross A |
| |
Institution: | PM Gross Chemical Laboratory, Duke University, Durham, North Carolina 27708-0346, USA. |
| |
Abstract: | reaction: see text] Reaction of enyne 1 with catecholborane catalyzed by a 1:1 mixture of Rh(COD)(2)](+)SbF(6)(-) and (S)-BINAP (5 mol %) followed by Pd-catalyzed arylation with p-IC(6)H(4)CF(3) gave benzylidenecyclopentane 5 in 65% yield with 88% ee. Rhodium-catalyzed asymmetric cyclization/hydroboration followed either by Pd-catalyzed arylation or by oxidation was applied to the synthesis of a number of chiral, nonracemic carbocycles and heterocycles. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|