Arylation of halogenated pyrimidines via a Suzuki coupling reaction |
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Authors: | Schomaker J M Delia T J |
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Institution: | Malcolm H. Filson Laboratories, Department of Chemistry, Central Michigan University, Mt. Pleasant, Michigan 48859, USA. |
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Abstract: | The Suzuki coupling reaction has been used extensively for the synthesis of a wide variety of unsymmetrical biaryl compounds. We have extended this reaction to demonstrate the utility of preparing monophenyl-, diphenyl-, or triphenylpyrimidine depending on the reaction conditions. Further, it has been shown that chloropyrimidine substrates are preferable over iodo-, bromo-, or fluoropyrimidines. |
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