On the effect of a point mutation on the reactivity of CuZn superoxide dismutase: a theoretical study |
| |
Authors: | Amadei Andrea D'Alessandro Maira Paci Maurizio Di Nola Alfredo Aschi Massimiliano |
| |
Institution: | Dipartimento di Scienze e Tecnologie Chimiche Università di Roma "Tor Vergata", Via della Ricerca Scientifica 1, 00133 Roma, Italy. andrea.amadei@uniroma2.it |
| |
Abstract: | In this paper, we investigate the effects of a point mutation on the enzymatic activity of copper-zinc superoxide dismutase, which we recently studied in detail by means of a theoretical-computational procedure. Comparison of the reactivity of the initial catalytic steps in this mutant (G93A mutation far from the active site) with our previous data, reveals the beautiful mechanical-dynamical architecture of the enzyme, altered by such an apparently irrelevant mutation. Finally, our results suggest a possible atomic-molecular-based explanation for the mutant-pathology correlation, in line with the most recent experimental data. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|