A Novel and Expedient Synthesis of 7‐Pyrimidinylpyrimido[4,5‐d]pyrimidinones |
| |
| Authors: | Mohammad?R Mohammadizadeh Mojtaba Bahramzadeh Ali?A Mohammadi Ali?R Karimi |
| |
| Institution: | 1. Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran, (phone/fax: +98?(771)?4541494);2. Chemistry Department, Faculty of Science, Islamic Azad University‐Sabzevar Branch, P.?O. Box 9618814711, Sabzevar, Iran;3. Department of Chemistry, Arak University, Arak 38156, Iran |
| |
| Abstract: | A novel and efficient procedure for the synthesis of new 7‐pyrimidinylpyrimido4,5‐d]pyrimidinone derivatives was elaborated via the base‐promoted cyclodimerization reaction of 5‐(dimethylamino)methylidene]‐6‐iminopyrimidine‐2,4(1H,3H)‐dione hydrochlorides. In an analogous manner, a 2‐thioxo analog was prepared starting with the corresponding 2‐thioxopyrimidin‐4‐one. |
| |
| Keywords: | Pyrimido[4 5‐d]pyrimidinone derivatives 7‐pyrimidinyl‐ Cyclodimerization reactions 6‐Aminouracil Pyrimidine‐2 4(1H 3H)‐dione 6‐imino‐ |
|
|
