Analytical Potentialities of Carbon Nanotube/Silicone Rubber Composite Electrodes: Determination of Propranolol |
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| Authors: | Sidney Xavier dos Santos Éder T G Cavalheiro Christopher M A Brett |
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| Institution: | 1. Departamento de Química e Física Molecular, Instituto de Química de S?o Carlos, Universidade de S?o Paulo, C.P. 676, 13560‐970 S?o Carlos/SP, Brazil;2. Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 3004‐535 Coimbra, Portugal |
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| Abstract: | A new composite electrode based on multiwall carbon nanotubes (MWCNT) and silicone‐rubber (SR) was developed and applied to the determination of propranolol in pharmaceutical formulations. The effect of using MWCNT/graphite mixtures in different proportions was also investigated. Cyclic voltammetry and electrochemical impedance spectroscopy were used for electrochemical characterization of different electrode compositions. Propranolol was determined using MWCNT/SR 70 % (m/m) electrodes with linear dynamic ranges up to 7.0 µmol L?1 by differential pulse and up to 5.4 µmol L?1 by square wave voltammetry, with LODs of 0.12 and 0.078 µmol L?1, respectively. Analysis of commercial samples agreed with that obtained by the official spectrophotometric method. The electrode is mechanically robust and presented reproducible results and a long useful life. |
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| Keywords: | Carbon nanotubes Silicone rubber Composite electrodes Propranolol Nanotubes |
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