Challenging the absence of observable hydrogens in the assignment of absolute configurations by NMR: application to chiral primary alcohols |
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| Authors: | Freire Félix Seco José Manuel Quiñoá Emilio Riguera Ricardo |
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| Affiliation: | Departamento de Química Orgánica, Facultad de Química, and Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain. |
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| Abstract: | The absolute configuration of beta-chiral primary alcohols devoid of observable hydrogens on one of the beta-substituents at the asymmetric carbon (L(1)/L(2)) can be determined by comparison of the (1)H NMR of their (R)- and (S)-9-AMA ester derivatives and analysis of the Deltadelta(RS) for the L substituent and the Cbeta-H. |
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