Synthesis and cercaricidal activities of a serial of novel self-diffused cercaricides derived from niphensamide |
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Authors: | Wei Guo Lv Yin Zheng Yong Quan Wu Xiao Lin Fan |
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Institution: | Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China |
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Abstract: | A serial of novel cercaricides that can self-diffuse on the water surface were designed and synthesized according to the special habit of cercariae larvae.These compounds were derived from niphensamide.While the compounds were dropped on the surface of water,the liquor diffused along the air-water interface and formed thin membranes floating on the water surface immediately.The strong cercaricidal activities against the cercariae larvae of Schistosome japonicum of these compounds have been revealed by further experiments. |
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Keywords: | Niphensamide Self-diffused cercaricide Cercariae larvae |
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